Commonly known as fennel, Foeniculum Vulgare is used to treat symptoms of sluggish digestion and intestinal dysbiosis, or a negative change in the composition of gut bacteria. These conditions can cause uncomfortable symptoms such as bloating, flatulence, and constipation. The European Medicines Agency (EMA) has found that Foeniculum Vulgare may be therapeutic in treating digestive symptoms caused by bacterial imbalances and slow digestive transit.

Cassia Angustifolia, also known as senna, is a stimulant laxative. Senna is a common ingredient in many laxatives due to its effectiveness and safety.

In a 2010 clinical trial involving 20 patients with constipation, it was noted that senna infusions increased the subjects' daily bowel movements. They also reported an improvement in overall bowel function. No significant side effects were found, except for a slight reduction in blood potassium levels during the treatment period. The study concluded that senna is an effective laxative and a safe option for treating constipation.

Rhamnus Purshiana, also known as Cascara, has historically been used to treat constipation and detoxify the colon. There are two main laxative components in Cascara, hydroxyanthracene glycosides (specifically cascarosides A, B, C, and D) and emodin. Similar to senna, these stimulate bowel activity.
Hydroxyanthracene glycosides stimulate intestinal movement by retaining water and electrolytes in the large intestine, increasing bowel volume and voiding pressure.

Emodin contributes to the herb's laxative effect by activating smooth muscle cells in the large intestine to relieve constipation.

Papaya has many benefits, including anti-parasitic and anti-constipation properties. In fact, papaya has anti-inflammatory properties that help fight digestive problems, and its high fiber content improves intestinal transit.

Thanks to its laxative and detoxifying properties, papaya can help us cleanse ourselves of toxins and residues that accumulate in the intestine, in order to improve its functioning.

More commonly known as "bitter aloe," Aloe Ferox is primarily used as a safe and effective natural laxative. Several studies have shown that Aloe Ferox improves intestinal motility and increases fecal bulk. A 2011 study found Aloe Ferox to be an effective remedy for constipation. It has also been linked to improving symptoms of cardiovascular disease, cancer, neurodegeneration, and diabetes. A 2012 study found Aloe Ferox to be effective in treating gastrointestinal parasites, which can affect digestion if left untreated. Researchers have found the plant has the potential to be used as an anthelmintic or antiparasitic drug.

Cardamom is used for digestive problems, including heartburn, intestinal spasms, irritable bowel syndrome (IBS), intestinal gas, constipation, liver and gallbladder disorders, and loss of appetite. Cardamom contains chemicals that appear to treat stomach and intestinal spasms and gas and increase the movement of food through the intestine.

Rhamnus Frangula, commonly known as frangula bark, has a long history of medicinal use. However, research is catching up on its effectiveness for digestive problems. The EMA recently reviewed 10 years of research on the effectiveness of frangula bark in combination with other laxatives in a detailed report on frangula bark. In this assessment, the EMA also considered expert opinion and clinical experience. The report concluded that frangula bark is effective and safe for constipation based on well-established evidence.